AHA 2023 CardioNerds Conference Scholars Late-Breaking Video Collection
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8m 35sPart 1 | Session 5 CordiO App: Speech Analysis to Detect Worsening HF in ADHF Patients
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14m 32sPart 1 | Session 6 AHA23: Presidential Advisory on Cardiovascular-Kidney-Metabolic Health
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10m 36sPart 1 | Session 7 AZALEA-TIMI 71: Abelcibab Vs Rivaroxaban in Patients with AF
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9m 14sPart 1 | Session 8 An Extended Duration Short-Interfering RNA Targeting Lp(a)
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11m 15sPart 1 | Session 9 ARTESiA: Stroke Risk Reduction in Sub-Clinical AF: Apixaban vs Aspirin
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15m 26sPart 1 | Session 10 ARIES HM3: Avoidance of Aspirin with LVAD Devices
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14m 58sPart 1 | Session 1 ORBITA-2: PCI for Stable Angina
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11m 47sPart 1 | Session 2 SELECT: Effects of Semaglutide on Heart Disease & Stroke in Obese Patients
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16m 5sPart 1 | Session 3 MINT: Myocardial Ischaemia & Transfusion
AHA 2023 — Investigator, Dr George Bakris (UChicago Medicine, US) is interviewed by Dr Sukriti Banthiya, CardioNerds Ambassador on the new findings of KARDIA-1 trial (NCT04936035).
This randomized, double-blind, placebo-controlled, dose-ranging multicenter study (Alnylam Pharmaceuticals) aimed to evaluate the effect of ALN-AGT01 (zilbesiran) on systolic and diastolic blood pressure in patients with mild to moderate hypertension. 394 participants were enrolled in the trial and were randomised to receive either ALN-AGT01 or placebo. At 6 months, placebo participants were randomized to receive one of the initial ALN-AGT01 regimens until the end of the 12-month treatment period.
The primary endpoint is the change from baseline at three months in 24-hour mean systolic blood pressure (SBP) assessed by ambulatory blood pressure monitoring (ABPM).
Results suggest that single subcutaneous doses of zilbesiran showed clinically significant reductions in 24-hour mean SBP as compared to placebo at 3 months, which was sustained through to month 6. An encouraging safety profile was demonstrated across this period, with low rates of serious or severe adverse events, and mild to moderate drug-related events observed across all zilbesiran regimens. Study of the drug will continue in the ongoing KARDIA-2 phase 2 study.
Recorded on-site at AHA 2023, Philadelphia.
Supported by an educational grant from Novo Nordisk Inc. This content is not intended for UK HCPs.
In 2023, we are excited to partner with @CardioNerds, a dynamic team dedicated to democratizing cardiovascular education. Experience a fresh perspective on the new data through an interview series featuring principal investigators and ambassadors from the CardioNerds family.
These interviews are supported by an educational grant from Novo Nordisk Inc. This content is not intended for UK HCPs.
More from this programme
Faculty Biographies
George L Bakris
President Elect
Dr George L. Bakris, MD, is a distinguished member of the National Kidney Foundation's Board of Directors. As the Professor of Medicine and Director of the Comprehensive Hypertension Center at the University of Chicago Medicine, he brings a wealth of expertise to the forefront of medical education.
Previously serving as the Vice-Chairman of Preventive Medicine and Director of the Rush University Hypertension Center in Chicago, Dr Bakris has made significant contributions to the understanding of hypertension, diabetic kidney disease, and nephropathy progression. With a prolific publication record boasting over 700 articles and book chapters, his work has significantly impacted the landscape of cardiovascular research.
Dr Bakris has played a pivotal role in shaping national guidelines, serving on committees such as the Joint National Committee (JNC) Writing Groups VI & 7, the JNC 7 executive committee, the American Diabetes Association Clinical Practice Guideline…
Sukriti Banthiya
Fellow physician
Sukriti Banthiya is a Cardiology Fellow at Henry Ford Providence Hospital. A visual learner and self-taught artist, she loves to learn using art as an aid to simplify complex concepts in medicine, with a focus on adult congenital heart disease. She is the author of “Learning Medicine with Art”, a compilation of medical illustrations which aims to make learning fun for the medical student! She was awarded the Carole Warnes Scholarship and hopes to pursue a career in adult congenital electrophysiology.
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