ACC.24: Late-Breaking Science Video Collection

Published: 06 April 2024

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Overview

Our recurring review series, View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offers a thorough examination of late-breaking and featured scientific findings, highlighting significant data.

 

To delve deeper into the pivotal clinical trial data unveiled at ACC 24, Dr Harriette Van Spall (McMaster University, Hamilton, CA) conducts interviews with the principal investigators as part of her Late-Breaker Discussion Series.

 

For brief and focused coverage of the essential data unveiled, our accessible Expert Interviews were conducted with a select group of faculty members, concentrating on the results, relevance, and implications for future research.

 

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

More from this programme

Part 1

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC.24. 

Part 2

Late-Breaker Discussion Series

Part 5

Behind the Heart

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

About the episode

ACC.24 — Investigator Dr Moritz Seiffert (University Heart and Vascular Center Hamburg, DE) joins us onsite at ACC to discuss the findings of the DEDICATE-DZHK6 Trial (NCT03112980).

This randomized controlled, multi-center trial aimed to investigate whether transcatheter aortic valve implantation (TAVI) is non-inferior to surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis at low to intermediate operative risk of mortality, as measured by all-cause mortality or stroke at 1 and 5 years. 1414 patients were enrolled in this trial, and were randomized in a 1:1 fashion to receive either TAVI or SAVR.

Findings showed that, among patients with severe aortic stenosis at low or intermediate surgical risk, TAVI with prosthesis selection based on operator discretion was non-inferior to SAVR in regard to risk of death from any cause or stroke at 1 year.

Interview Questions:

  1. What is the importance of this study?
  2. What was the study design and patient population?
  3. What are the key findings?
  4. How should these findings impact clinical practice?
  5. What is the main take-home message?
  6. Where are the knowledge gaps?

Recorded remotely from Atlanta, 2024.

Faculty Biographies

Moritz Seiffert

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