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2m 30sPart 3 | Session 11 TAVI Vs SAVR in Patients with Severe Aortic Valve Stenosis: DEDICATE-DZHK6
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4m 17s
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6m 45sPart 4 | Session 1 Artificial Intelligence in Cardiology: What You Need to Know in 2024
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6m 21sPart 4 | Session 2 Weight Loss Medications: What You Need to Know in 2024
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43m 48sPart 1 | Session 1 ACC.24 Late-breaking Science Wrap Up
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28m 9sPart 1 | Session 2 What's Hot at ACC.24? Late-breaking Science Preview
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22m 43sPart 2 | Session 1 Late-Breaker Discussion: The EMPACT-MI Trial
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14m 7sPart 2 | Session 2 Late-Breaker Discussion: The AEGIS-II Trial
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29m 8sPart 2 | Session 3 Late-Breaker Discussion: The RELIEVE-HF Trial
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23m 6sPart 2 | Session 4 Late-Breaker Discussion: The ARISE-HF Trial
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5m 50s
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7m 49sPart 3 | Session 2 Zilbesiran in Patients With Hypertension: KARDIA-2
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3m 40s
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7m 18s
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6m 40sPart 3 | Session 5 Chelation Therapy in Post-MI Pts with Diabetes: TACT2
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6m 41sPart 3 | Session 6 Semaglutide in Patients with HfpEF, Obesity and Diabetes: STEP HFpEF
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5m 41sPart 3 | Session 7 Self-Expanding vs Balloon Expandable TAVR: The SMART Trial
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3m 37s
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4m 35sPart 3 | Session 9 Technology-Assisted Nonprescription Rosuvastatin: TACTiC
ACC.24 — Investigators, Dr Rasha K Al-Lamee and Dr Michael Foley (Imperial College London, UK) joined us to discuss the ORBITA COSMIC trial (NCT04892537).
This randomized, double-blinded, placebo-controlled trial investigated the effects of coronary sinus reducer (CSR) as compared to placebo on myocardial perfusion via MRI, exercise duration, and symptoms in patients with refractory angina and ischemia. Fifty patients with stable coronary artery disease (CAD), ineligible for percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG), were enrolled in the trial.
Findings demonstrated that CSR showed no improvement in transmural myocardial perfusion, but improved subendocardial perfusion. Findings showed a reduced angina frequency, and improved heart disease related quality of life.
Questions
- What is the importance of ORBITA COSMIC?
- Could you tell us about the study device?
- What was the study design, eligibility criteria, and endpoints?
- What are the key results?
- Can you share more details about the mechanism of action?
- What are the take-home messages?
- What are the next steps?
Support: This is an independent interview conducted by Radcliffe Cardiology.
Recorded on-site at ACC.24, Atlanta.
Interviewer: Mirjam Boros
Editor: Jordan Rance
Videographer: Dan Brent, Tom Green, Mike Knight
Our recurring review series, View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offers a thorough examination of late-breaking and featured scientific findings, highlighting significant data.
To delve deeper into the pivotal clinical trial data unveiled at ACC 24, Dr Harriette Van Spall (McMaster University, Hamilton, CA) conducts interviews with the principal investigators as part of her Late-Breaker Discussion Series.
For brief and focused coverage of the essential data unveiled, our accessible Expert Interviews were conducted with a select group of faculty members, concentrating on the results, relevance, and implications for future research.
Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.
More from this programme
Part 1
View from the Thoraxcenter
In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC.24.
Part 2
Late-Breaker Discussion Series
Host, Dr Harriette Van Spall is joined by principal investigators for discussion on selected late-breaking trials.
Part 3
Expert Interviews
Part 4
Highlights
Part 5
Behind the Heart
Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.
Faculty Biographies
Rasha Al-Lamee
Interventional Cardiology Consultant
Dr Rasha Al-Lamee is an interventional cardiology consultant at Imperial College Healthcare NHS Trust, London, UK.
Dr Al-Lamee studied at the University of Oxford and University College London. She completed her training in clinical cardiology on the north-west London cardiology rotation in 2013, and completed her PhD at Imperial College London in 2018.
Dr Al-Lamee’s research interests are complex coronary intervention, coronary physiology and invasive intravascular assessment. She designed, conducted and led the ORBITA trial and is lead author of the primary publication in The Lancet. Dr Al-Lamee has more than 50 peer-reviewed publications and has presented at international cardiology conferences worldwide.
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