ACC.24: Late-Breaking Science Video Collection

Published: 06 April 2024

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Overview

Our recurring review series, View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offers a thorough examination of late-breaking and featured scientific findings, highlighting significant data.

 

To delve deeper into the pivotal clinical trial data unveiled at ACC 24, Dr Harriette Van Spall (McMaster University, Hamilton, CA) conducts interviews with the principal investigators as part of her Late-Breaker Discussion Series.

 

For brief and focused coverage of the essential data unveiled, our accessible Expert Interviews were conducted with a select group of faculty members, concentrating on the results, relevance, and implications for future research.

 

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

More from this programme

Part 1

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC.24. 

Part 2

Late-Breaker Discussion Series

Part 5

Behind the Heart

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

About the episode

ACC.24 — Investigator, Dr Steven Nissen joins us onsite to discuss the findings of a trial designed to evaluate the extent to which participants could safely and effectively select, purchase and use rosuvastatin calcium 5mg for a 6-month trial period (NCT04964544).

The TACTiC trial is a single-arm interventional, phase III self-selection and actual use study implementing a technology assisted tool within a web app. Around 1220 patients were enrolled in the study, with 1196 participants proceeding to the use phase. Primary outcome measures included the percentage of participants with an overall correct initial TASS outcome at the initial self selection, an overall correct final use outcome at the final use assessment, and percent baseline change in verified LDL-C. 

Findings first revealed at ACC showed that overall concordance between consumers and clinicians for initial self-selection was 90.7% (95% CI, 88.9 to 92.3). Final use assessment was concordant in 98.1% (95% CI, 97.1 to 98.8), with a mean change in LDL-C of -35.5% (95% CI, -36.6 to -34.3). Participants also had a high level of adherence, with no major safety issues.

Interview Questions:

  1. What is the importance of this study?
  2. What was the study design and enrolment?
  3. Could you tell us more about how the participant would use the web app?
  4. What were the key findings?
  5. Based on these findings, what are the implications for clinical practice?
  6. What are the knowledge gaps?
  7. What are the next steps?

Recorded onsite at the ACC Conference in Atlanta, 2024.

Faculty Biographies

Steven E Nissen

Steven E Nissen

Cleveland Clinic, Cleveland, US

Dr. Steven E. Nissen, an esteemed American cardiologist, researcher, and patient advocate, has left an indelible mark in the field of cardiology. Formerly the chairman of cardiovascular medicine at the renowned Cleveland Clinic in Ohio, Dr. Nissen brings a wealth of experience and expertise to his roles.

Joining the Cleveland Clinic in 1992, Dr. Nissen held key positions, including Vice-Chairman of the Department of Cardiology, Section Head of Clinical Cardiology, and Director of the Coronary Intensive Care Unit. In his most recent role, he served as the Medical Director of the Cleveland Clinic Cardiovascular Coordinating Center (C5), overseeing multi-center clinical trials. Dr. Nissen continues to contribute periodically in the Cardiac Critical Care Unit, showcasing his ongoing commitment to patient care.

A highly accomplished academic, Dr. Nissen graduated from the Webb School of California before pursuing his undergraduate degree at the University of Michigan. He…

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