ACC.24: Late-Breaking Science Video Collection

Published: 06 April 2024

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Overview

Our recurring review series, View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offers a thorough examination of late-breaking and featured scientific findings, highlighting significant data.

 

To delve deeper into the pivotal clinical trial data unveiled at ACC 24, Dr Harriette Van Spall (McMaster University, Hamilton, CA) conducts interviews with the principal investigators as part of her Late-Breaker Discussion Series.

 

For brief and focused coverage of the essential data unveiled, our accessible Expert Interviews were conducted with a select group of faculty members, concentrating on the results, relevance, and implications for future research.

 

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

More from this programme

Part 1

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC.24. 

Part 2

Late-Breaker Discussion Series

Part 5

Behind the Heart

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

About the episode

ACC.24 — Investigator, Dr Howard C Hermann (Penn Medicine, Philadelphia, PA, US) joins us to discuss the findings from the SMART Trial (NCT04722250).

This prospective, multi-center, randomized controlled study aims to investigate the valve safety and performance of self expanding as compared to balloon-expandable transcatheter aortic valve replacement (TAVR) in patients with small aortic annuli and severe symptomatic aortic stenosis. At select sites, a stress echocardiography sub-study also evaluated the performance of self expandable and balloon-expandable TAVR in this patient group, after exercise stress testing.

716 patients were enrolled in the trial, and were randomized on a 1:1 basis to receive TAVR with either a Medtronic self-expanding transcatheter aortic valve, or an Edwards balloon-expandable transcatheter heart valve.

Findings showed that the trial met both primary endpoints, with no significant difference between groups in terms of a composite of death, disabling stroke or rehospitalization for heart failure, which occurred in 9.5% of patients with the self-expandable valve, and 10.6 of those with the balloon-expandable valve. In terms of valve function, the self-expandable valve was found to be superior in a composite of structural and non-structural valve deterioration, blood clotting around the valve, infection of the valve and aortic valve reintervention.

Interview Questions:

  1. What is the importance of this study?
  2. Could you tell us a bit more about the devices used in this study, and why SE and BE devices are compared in this patient group?
  3. What are the key findings?
  4. What is the impact of these findings on clinical practice?
  5. What is your take-home message?
  6. What further research is required?

Recorded onsite at the ACC Conference in Atlanta, 2024.

Faculty Biographies

Howard C Herrmann

Howard C Herrmann

Director, Cardiac Catheterization Laboratories

Howard C Herrmann, MD, is a Professor of Medicine at the University of Pennsylvania School of Medicine and Director of Interventional Cardiology and the Cardiac Catheterization Laboratories at the Hospital of the University of Pennsylvania, Philadelphia. He has authored or co-authored more than 200 articles on numerous topics in interventional cardiology. His research focuses on the clinical investigation of new therapies for valvular and structural heart disease. He is Past President of the Pennsylvania Chapter of the American College of Cardiology (ACC) and serves on numerous national committees and Editorial Boards. Dr Herrmann earned his AB at Harvard College and his MD at Harvard Medical School, and completed his training at Massachusetts General Hospital.

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