ACC.24: Late-Breaking Science Video Collection

Published: 06 April 2024

  • Views:

    Views Icon 4961
  • Likes:

    Heart Icon 7
Average (ratings)
No ratings
Your rating

Overview

Our recurring review series, View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offers a thorough examination of late-breaking and featured scientific findings, highlighting significant data.

 

To delve deeper into the pivotal clinical trial data unveiled at ACC 24, Dr Harriette Van Spall (McMaster University, Hamilton, CA) conducts interviews with the principal investigators as part of her Late-Breaker Discussion Series.

 

For brief and focused coverage of the essential data unveiled, our accessible Expert Interviews were conducted with a select group of faculty members, concentrating on the results, relevance, and implications for future research.

 

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

More from this programme

Part 1

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC.24. 

Part 2

Late-Breaker Discussion Series

Part 5

Behind the Heart

Watch our Behind the Heart series to learn more the personal perspectives from the investigators behind top trials in cardiovascular science.

About the episode

ACC 24 - In this video, Dr Gervasio L Lamas (Mount Sinai Medical Center, US) joins us onsite to discuss the findings from the TACT2 study of chelation therapy in post-myocardial infarction patients with diabetes (NCT02733185).

The Trial to Assess Chelation Therapy 2 (TACT2) study is a randomized, double blind factorial clinical trial, aiming to determine if chelation-based strategy increases the time to the first occurrence of all-cause mortality, myocardial infarction, stroke, coronary revascularization or hospitalisation for unstable angina as compared to placebo. This is a 2x2 factorial trial, testing 40-weekly edetate disodium-based chelation infusions and twice daily high-dose oral multivitamins and minerals. 1000 patients with diabetes were enrolled into the study.

Findings showed that EDTA chelation produced a >60% reduction in blood lead levels, however, it did not result in a significant clinical benefit on the primary or secondary endpoints, or on all-cause mortality. 

Interview Questions:

  1. What is the importance of this study?
  2. What is the mechanism of action behind chelation therapy?
  3. What was the study design and patient population?
  4. What are your key findings?
  5. What should be the impact of these findings on clinical practice?
  6. What further study is needed, and what are the next steps?

Recorded onsite at the ACC Conference in Atlanta, 2024.

Faculty Biographies

Gervasio Lamas

Mount Sinai Medical Center, Miami Beach, FL, US

View full profile

Comments

You must be to comment. If you are not registered, you can register here.