ACC 2023: Late-Breaking Science Video Collection

Published: 06 March 2023

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Our regular review series View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) provides a critical analysis of the late-breaking and featured science results and spotlights impactful data. 


For a deeper look into the key clinical trial data revealed at ACC 23, Dr Harriette Van Spall (McMaster University, Hamilton, CA) interviews the principal investigators in her regular Late-Breaker Discussion Series


For short, concise coverage of the key data revealed, our accessible Expert Interviews were conducted with select faculty, focussing on the results, applicability and impact on future research. 

More from this programme

Part 3

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC 2023. 

About the episode

Professor Marius Hoeper (Hannover Medical School, DE) joins us to outline the findings of the late-breaking STELLAR phase III trial.

The STELLAR Trial aims to study the safety and efficacy of sotatercept (MK-7962) and background pulmonary arterial hypertension (PAH) therapy in patients with PAH as compared to placebo. The investigators hypothesized that participants receiving sotatercept would have improved 6-minute walk distance at 24 weeks when compared to the placebo arm. 324 participants were enrolled in the trial.

Data presented in New Orleans showed that in patients with pulmonary arterial hypertension who were receiving stable background therapy, sotatercept resulted in a greater improvement in exercise capacity. 


  1. What is the background of this study?
  2. What was the patient population and study design?
  3. What are the key findings?
  4. What is the implication of these findings on both clinical practice, and future research?
  5. What further study is needed?

Recorded on-site at ACC.23/WCC, New Orleans. 

Faculty Biographies

Marius Hoeper

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