ACC 2023: Late-Breaking Science Video Collection

Published: 06 March 2023

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Our regular review series View from the Thoraxcenter, hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) provides a critical analysis of the late-breaking and featured science results and spotlights impactful data. 


For a deeper look into the key clinical trial data revealed at ACC 23, Dr Harriette Van Spall (McMaster University, Hamilton, CA) interviews the principal investigators in her regular Late-Breaker Discussion Series


For short, concise coverage of the key data revealed, our accessible Expert Interviews were conducted with select faculty, focussing on the results, applicability and impact on future research. 

More from this programme

Part 3

View from the Thoraxcenter

In these concise episodes of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcentre, Erasmus MC, Rotterdam, NL) offer their thoughts on the top late-breaking trials that will be presented at ACC 2023. 

About the episode

In this short interview from the ACC's 2023 Scientific Sessions, Dr Barry Borlaug (Mayo Clinic, US) joins us virtually to discuss a trial which aims to evaluate the mechanism of benefit for dapagliflozin in patients with heart failure with preserved ejection fraction (Mayo Clinic). The study was conducted over 6 months with 43 patients enrolled in the trial. 

The main findings suggest that pulmonary capillary wedge pressure at rest and during exercise was significantly reduced in patients who were treated with dapagliflozin as compared to placebo.


  1. What was the reasoning behind this trial?
  2. What was the patient population and study design?
  3. What are your main findings?
  4. How does this trial contribute to our understanding of the potential benefits of dapagliflozin in patients with HFpEF?
  5. What are the implications of these findings for clinical practice, and how might they inform future research?
  6. Why should people be interested in this data?

Recorded remotely from Minnesota, 2023.

Faculty Biographies

Barry Borlaug

Barry Borlaug

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