Search results
Author(s):
Gaku Nakazawa
,
Aloke V Finn
,
Renu Virmani
Added:
3 years ago
Polymer-based sirolimus (Cypher®) and paclitaxel (Taxus®) drug-eluting stents (DES) have reduced rates of restenosis and target lesion revascularization (TLR) compared with bare-metal stents (BMS) and have launched a revolution in the interventional treatment of symptomatic coronary artery disease.1,2 However, this overwhelming enthusiasm has recently been dampened by safety concerns regarding a…
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Author(s):
Giora Weisz
Added:
3 years ago
Much has been written, but little is known, about the long-term outcomes after drug-eluting stent (DES). The introduction of DES has extended the use of stents from a passive platform for vessel wall scaffolding to an active biotechnology vehicle for local delivery of antiproliferative pharmacotherapy. Like any other therapy or medical technology, no treatment is perfect and free of potential…
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Dual Anti-platelet Therapy after Coronary Stenting: Rationale for Personalized Duration of Therapy
Author(s):
Donald E Cutlip
Added:
3 years ago
Article
Author(s):
Peter J Fitzgerald
,
Martin B Leon
Added:
3 years ago
An unintended consequence of the market success of drug-eluting stents has been a growing concern about their safety and safety-related costs. These devices have been so quickly and widely adopted that their market penetration already equals that of some of the most popular pharmaceutical drugs. Consequently, the absolute significance of even a low incidence of side effects becomes magnified by…
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Author(s):
Peter J Fitzgerald
,
Martin B Leon
Added:
3 years ago
An unintended consequence of the market success of drug-eluting stents has been a growing concern about their safety and safety-related costs. These devices have been so quickly and widely adopted that their market penetration already equals that of some of the most popular pharmaceutical drugs. Consequently, the absolute significance of even a low incidence of side effects becomes magnified by…
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Drug-eluting Stent Failures
Author(s):
Neville Kukreja
,
Patrick W Serruys
Added:
3 years ago
Article
Author(s):
Albert Alahmar
,
Anthony H Gershlick
Added:
3 years ago
Drug-eluting stents (DES) have revolutionized the field of interventional cardiology. The US Food and Drug Administration (FDA) is expecting that the total number of DES implanted in 2010 will surpass 5 million worldwide. Although initial results seemed promising, longer-term follow-up in a wider range of patients revealed some concerns. Enhanced platelet aggregation, delayed neointimal growth, a…
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Author(s):
Ziad A Ali
Added:
7 months ago
ESC 2023 — Dr Ziad Ali (DeMatteis St Francis, US) joins us to discuss the findings from the ILUMIEN IV clinical trial (NCT03507777).
ILUMIEN IV (Abbott Medical Devices)is a prospective, single-blind clinical trial aiming to compare optical coherence tomography (OCT) to an angiography-guided stent implantation strategy. The trial investigated which method achieved a larger post-percutaneous…
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Author(s):
Colin T Phillips
,
Michael C Gavin
Added:
3 years ago
Acute coronary syndrome (ACS) occurs most often when a vulnerable intracoronary plaque ruptures or erodes to expose a prothrombotic core, precipitating thrombus formation by way of platelet activation,1–3 The spectrum of ACS includes non-ST segment-elevation (NSTE) ACS, where a vulnerable plaque threatens downstream coronary perfusion manifest as an increase in symptom frequency and/or duration …
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Author(s):
Masahiro Natsuaki
Added:
7 months ago
ESC 23 — Dr Masahiro Natsuaki (Saga University, JP) discusses the short and optimal duration of dual antiplatelet therapy-3 Study (STOPDAPT-3) (NCT04609111).
In the STOPDAPT-2 study, 1-month dual antiplatelet therapy (DAPT) followed by clopidogrel monotherapy was shown to provide benefits in bleeding reduction over a 12-month period, however, other trials have shown high rates of bleeding at…
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