Search

Search results

Current Evidence and Future Directions of PCSK9 Inhibition

… addition to statin therapy. More recently, inclisiran, a silencing RNA (siRNA) that inhibits translation of PCSK9 mRNA, … , proprotein convertase subtilisin/kexin type 9 , silencing RNA , Received: 30 March 2020 Accepted: 10 …

Type:

Article

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Inhibition in Patients With or at High Risk of Coronary Heart Disease

… monoclonal antibodies, antisense oligonucleotides, and RNA interference technology. Twomonoclonal antibodies to … inclisiran - a molecule that inhibits PCSK9 synthesis by RNA interference - is currentlyunder development. Phase 1 and … up by hepatocytes and directly bind to the RNA-induced silencing complex (RISC), part of the cells natural …

Type:

Article

ACC 2020: Inclisiran Potently and Durably Reduces LDL-C

… Inclisiran work ? [Wright] Inclisiran is a double stranded RNA that's sort of a new and novel treatment for treating … into the hepatocyte, it uses the body's natural process of silencing the translation of messenger RNA through the RISC complex. And it inhibits the translation …

Type:

Video

AHA 2019: RNA Interference Targeting Apolipoprotein C-III

… Video AHA 2019: RNA Interference Targeting Apolipoprotein C-III - Dr James … Development at Arrowhead Pharmaceuticals) discusses RNA Interference Targeting Apolipoprotein C-III (APOC3) …

Type:

Video

James Hamilton

… Pharmaceuticals Read more Author videos Video AHA 2019: RNA Interference Targeting Apolipoprotein C-III James …

Type:

Author

New Developments in Nuclear Cardiac Imaging

… for motion-corrected first-pass radionuclide angiography (RNA) during treadmill upright exercise, is currently being … that allows performance of high-quality first-pass RNA studies during upright exercise. Furthermore, propriety … from time activity curve obtained during a first-pass RNA study. Other Tracers It is ironic that nuclear imaging …

Type:

Article

Amyloid Heart Disease

… (disruptors). TTR silencers are either small interfering RNA (siRNA) or antisense oligonucleotides that target TTR messenger RNA in the hepatocyte, halting the production of TTR protein. …

Type:

Article

Biological Therapies for Cardiac Arrhythmias

… gene therapy stems from the understanding of DNA and RNA as well as the comprehension that modifications in either …

Type:

Article