Search results
Author(s):
Evan A Stein
Added:
3 years ago
Proprotein convertase subtilisin/kexin type 9 (PCSK9), discovered in 2003, is a circulating protein produced predominantly in the liver that plays a significant role in the recycling of LDL receptors (LDLRs).1,2 The LDLR, which normally recycles about 100 times in its lifetime, is the primary pathway for LDL-cholesterol (LDL-C) clearance from circulation. Plasma PCSK9 binds to LDLRs along with…
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Author(s):
Jiaqian Xu
,
Michael D Shapiro
Added:
3 years ago
Author(s):
Shane Prejean
,
Todd M Brown
Added:
3 years ago
Proprotein convertases are proteolytic enzymes that activate proteins by post-translational alterations in protein structure. Proprotein convertase subtilisin/kexin 9 (PCSK9) is a proprotein convertase that binds and inactivates the low-density lipoprotein (LDL) receptor on the surface of hepatocytes resulting in higher levels of serum LDL cholesterol (LDL-C).1 Over-expression of PCSK9 leads to a…
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Author(s):
Jakub Podolec
,
Lukasz Niewiara
Added:
3 years ago
Atherosclerosis is the primary cause of coronary artery disease morbidity and mortality worldwide.1 Low-density lipoprotein cholesterol (LDL-C)- lowering therapies have already become one of the most important in the prevention of atherosclerosis complications.2 Evolocumab is a human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) and thus significantly…
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Author(s):
Edward T Carreras
,
Donna M Polk
Added:
3 years ago
Cardiovascular disease affects more than one-third of American adults and is the leading cause of mortality in the United States and worldwide.1 Only 4.5 % of those over the age of 20 meet the ideal levels of the seven metrics of cardiovascular health including cholesterol levels.1 Of modifiable risk factors, including smoking, hypertension, diabetes, and obesity, dyslipidemia has been shown to…
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Author(s):
Leo Buckley
,
Ahmed Aldemerdash
Added:
3 years ago
Cardiovascular disease is the leading cause of death in the US.1,2 Although advances in the prevention and treatment of cardiovascular disease have contributed to a decline in mortality rates, this favorable trend has slowed over the past several years.3 Recently, however, a revival of cardiovascular drug development has introduced new treatment options to the market, with several promising…
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Author(s):
Hisham A Badreldin
,
Khalid bin Saleh
,
Majed Al-Yami
Added:
3 years ago
WRAP-IT
The Worldwide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT) was a prospective multicenter study to determine the safety and efficacy of an absorbable surgical mesh envelope containing two antibiotics (minocycline and rifampin) in reducing infection incidence in patients with cardiac implantable electronic devices compared to standard care.1 Approximately 7,000…
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Author(s):
Robert Barcelona
Added:
1 year ago
Gender Disparities in PAD
Author(s):
Andrea Martinez
,
Jingwen Huang
,
Arash Harzand
Added:
1 month ago
Article
Author(s):
Atsushi Sakamoto
,
Anne Cornelissen
,
Yu Sato
,
et al
Added:
2 years ago