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Author(s): James De Lemos Added: 3 years ago
Acute coronary syndromes (ACS) is an umbrella term comprising a spectrum of clinical conditions ranging from unstable angina to non-ST elevation myocardial infarction and ST elevation myocardial infarction. ACS begins when an atherosclerotic plaque ruptures or erodes and a platelet-fibrin clot obstructs coronary blood flow. These critical disorders are a major cause of emergency medical care and… View more

Imaging & Diagnostics

MI/ACS
Author(s): Shanmugam Uthamalingam , James L Januzzi Added: 3 years ago
Several cardiac biomarkers may aid in the diagnostic and prognostic evaluation of acute and chronic heart failure. In this article we discuss more novel and emerging applications of such established cardiac biomarkers in heart failure and review emerging data for several other promising markers. Novel Applications of Established Cardiac Biomarkers—Natriuretic Peptides B-type natriuretic peptide… View more

Heart Failure

MI/ACS
Author(s): Wolfgang Koenig , Natalie Khuseyinova Added: 3 years ago
Atherosclerosis is characterized by a non-specific local inflammatory process accompanied by a systemic response. A number of prospective studies in initially healthy subjects and in patients with manifest atherosclerosis have now convincingly demonstrated a strong and independent association between even slightly elevated concentrations of various systemic markers of inflammation and a number of… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Suzanne J Baron , Robert P Giugliano Added: 3 years ago
Coronary artery disease remains the leading cause of death in the US and worldwide. Although the incidence of death due to coronary artery disease has declined over the last several years, the prevalence of coronary artery disease remains high, with the American Heart Association (AHA) estimating that over 81 million Americans suffer from cardiovascular disease and 2,200 people dying every day of… View more

Anticoagulation

Prevention & Chronic Conditions
Added: 1 year ago
HRX 22 - GPX Inc. CEO Javier Echenique (GPX Inc., Boston, MA, US) joins us to discuss CardioID - a novel AI Algorithm-based "bloodless blood test" that uses NT-proBNP biomarkers in patient monitoring for heart failure decompensation. The TRIBE-HF 2 study is currently underway for algorithm training and validation. Questions: 1. What are the clinical unmet needs in heart failure that led to the… View more

Heart Failure

Digital Health
Author(s): Aarti Asnani , Randall T Peterson Added: 3 years ago
Survival rates among patients diagnosed with cancer have improved dramatically over the past few decades. In 2016, there were an estimated 16 million cancer survivors in the United States, a number expected to increase to 20 million over the subsequent decade.1 One-third of these patients will survive at least 5 years after their initial cancer diagnosis, largely due to cancer therapies that are… View more

Heart Failure

CV Disease in Special Populations
Valentina Puntmann
Dr Valentina Puntmann is Deputy Head of Department and senior clinical investigator with subspecialty interest in mutimodality cardiovascular imaging and conduct of clinical trials using imaging biomarkers. Her research projects focus on the development of novel imaging biomarkers for the detection of cardiovascular injury, supporting risk stratification, prevention and therapy. She is chief… View more
COVID-19 Pandemic and Cardiovascular Disease
Author(s): Aniket S Rali , Andrew J Sauer Added: 3 years ago
In late December 2019, an outbreak of an unknown disease called a pneumonia of uncertain cause occurred in Wuhan, Hubei Province, China.1 Over the next few days, several independent laboratories identified the causative agent as a novel coronavirus.2–4 The WHO has temporarily named this virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the related infectious disease… View more

Vascular Disease and Surgery

Heart Failure
Role of High-sensitivity Cardiac Troponin in Acute Coronary Syndrome
Author(s): Mahesh Anantha Narayanan , Santiago Garcia Added: 3 years ago
Chest pain is one of the most common reasons for an emergency room (ER) visit in the US with almost 6 million ER visits annually.1 According to the fourth universal definition of MI, acute MI (AMI) requires a rise and/or fall in cardiac troponin (cTn) with at least one value above the 99th percentile upper reference limit.2,3 Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are the… View more

MI/ACS

Intervention
Author(s): Kiran K Khush , Sharon A Hunt Added: 3 years ago
The field of heart transplantation has evolved tremendously since Alexis Carrel first explanted a canine heart and anastomosed it to the carotid artery and jugular vein of a recipient dog in 1905.1 In 1960, Norman Shumway and Richard Lower at Stanford described a technique for orthotopic canine heart transplantation and demonstrated adequate physiologic function of the denervated heart.2 Their… View more

Vascular Disease and Surgery