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Cardiac Toxicity of Cancer Chemotherapy

… cytotoxic chemotherapies to newer targeted therapies and immune checkpoint inhibitors. Discuss the underlying molecular … Fulminant myocarditis with combination immune checkpoint blockade. N Engl J Med 2016; 375:1749 - 55. DOI: …

Type:

Webinar

Cardiac Toxicity of Cancer Chemotherapy

… from conventional cytotoxic agents to newer targeted and immune-based therapies. Common manifestations of … anthracyclines , trastuzumab , targeted therapies , immune checkpoint blockade , Disclosure: The authors have no conflicts of …

Type:

Article

Clinical Features and Outcomes of Patients with Chemotherapy-induced Takotsubo Syndrome

… Acute Myocarditis Mimicking Takotsubo Syndrome Recently, immune checkpoint inhibitors have been associated with acute … MG, Cohen JV, et al. Myocarditis in patients treated with immune checkpoint inhibitors. J Am Coll Cardiol …

Type:

Article

Carsten Tschöpe

… cell therapies to cure heart failure and the role of the immune system in heart failure. Read more …

Type:

Author

Biological Therapies for Cardiac Arrhythmias

… various potential and demonstrated toxicities, including immune and inflammatory responses and neoplasia. A new … reduced by 20%. 23 Creating an AV nodal site of Ca channel blockade. 24 Implanting fibroblasts to induce AV nodal … is proposed as a means for achieving regional atrial I Kr blockade without prolonging the QT interval 26 and achieving …

Type:

Article

The Role of Angiotensin Receptor Blockers in Cardiovascular Protection Beyond Blood Pressure Control

… Cardio-protective Effects of Angiotensin Receptor Blockers Blockade of the renin-angiotensin system (RAS) reduces … experimental model of streptozotocin-induced diabetes, RAS blockade: attenuated production of ROS; reduced oxidative … in left ventricular end-diastolic pressure (LVEDP). 15 RAS blockade may also reduce angiotensin II-mediated vascular …

Type:

Article

Management of Hypertension in African-Americans

… the ACCOMPLISH study. These two trials suggest that RAS blockade + CCB is a favorable combination compared with other … Trial (ONTARGET) is a comparison of combination RAS blockade with ACE inhibitor/angiotensin II receptor blocker … renal studies. Thus, this particular combination of RAS blockade with both ACE inhibitor/ARB may not be ideal for …

Type:

Article

Cardiac Transplantation - Status in 2011

… of acute rejection that reflect changes in the recipient's immune response through the use of gene expression profiling … risk of serious cardiovascular events. 30 Finally, direct immune function assays that monitor T-cell function (Immuknow … mortality. 41,42 The etiology of CAV involves both immune and non-immune mechanisms. From an immunologic …

Type:

Article

A Review of the Antihypertensive and Renal-protective Effects of Irbesartan

… | PubMed Anavekar NS, Solomon SD, Angiotensin II receptor blockade and ventricular remodelling, J Renin Angiotensin … BF, Kashihara N, Ecder T, Renal protective effect of RAAS blockade across the renal continuum, with a review of the … Ruggenenti P, ACE inhibition versus angiotensin receptor blockade: which is better for renal and cardiovascular …

Type:

Article

Arrhythmias in Pediatric Syndromes

… heart disease (most commonly a patent ductus arteriosus),immune deficiency, intermittent hypoglycemia, developmental … in heart, brain, gut (including pancreatic islet cells), immune system, and smooth muscle tissues. 23-24 The mutation …

Type:

Article