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Author(s): Kilmer S McCully Added: 3 years ago
Discovery of the Homocysteine Theory of Arteriosclerosis The American biochemist Vincent DuVigneaud discovered a new amino acid in 1932 by treating methionine with sulfuric acid. The structure of this amino acid is similar to cysteine, except for one extra carbon atom, hence the name homocysteine. Subsequent investigation established the role of homocysteine as an intermediate in sulfur amino… View more

Prevention & Chronic Conditions
Author(s): Kilmer S McCully Added: 3 years ago
Discovery of the Homocysteine Theory of Arteriosclerosis The American biochemist Vincent DuVigneaud discovered a new amino acid in 1932 by treating methionine with sulfuric acid. The structure of this amino acid is similar to cysteine, except for one extra carbon atom, hence the name homocysteine. Subsequent investigation established the role of homocysteine as an intermediate in sulfur amino… View more

Prevention & Chronic Conditions
Author(s): Wolfgang Herrmann , Rima Obeid Added: 3 years ago
Homocysteine (Hcy) is a non-essential, non-protein-forming amino acid that originates in methionine via a transmethylation reaction. Hcy is catabolized into methionine or cysteine. Methionine synthase and its co-factor, methylcobalamin, enhance the methylation of Hcy into methionine, where 5-methyl tetrahydrofolate donates its methyl group to Hcy. The trans-sulfuration pathway of Hcy catabolism… View more

Prevention & Chronic Conditions
Author(s): Peter H Jones Added: 3 years ago
High Residual Cardiovascular Risk in Diabetic Patients Treated with Statins According to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII), diabetes is a coronary heart disease (CHD) risk equivalent.1 One major factor contributing to the excess risk of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) is atherogenic dyslipidemia,… View more

Prevention & Chronic Conditions
Author(s): Deborah A Chyun Added: 3 years ago
Individuals with both type 1 and type 2 diabetes mellitus (DM) are known to be at high risk for developing coronary artery disease (CAD). The risk is two to three times greater in those with DM compared with those without, and is especially high in women with DM. An additional problem in individuals with DM is that, even with severe underlying CAD, many individuals may have atypical symptoms or… View more

Prevention & Chronic Conditions

MI/ACS
Author(s): Carl J Lavie , Richard V Milani Added: 3 years ago
The potential benefits of formal, phase II cardiac rehabilitation and exercise training (CRET) programs have recently been reviewed in great detail.1–3 However, despite the substantial proven benefits of this therapy, which are outlined in part in this review, recent data have emphasized that many patients are not referred to formal CRET,4 and a minority of patients (14% of patients with acute… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Omega-3 Fatty Acids—Science, Efficacy, and Clinical Use in Cardiology
Author(s): William E Butler Added: 3 years ago
Studies have shown that omega-3 fatty acids (FAs) can promote cardiovascular health by both primary and secondary prevention of cardiac disease, and most notably by reducing fatal cardiovascular events including sudden cardiac death (SCD). For example, recent evidence from secondary prevention trials has suggested that intake of 850mg/day of omega-3 FAs can reduce the risk of coronary heart… View more

Prevention & Chronic Conditions