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Author(s):
Jennifer S Li
,
YT Chen
,
Claire Morgan
,
et al
Added:
3 years ago
Overview
Pompe disease, also known as glycogen storage disease type II or acid maltase deficiency, is a rare, debilitating, and often fatal lysosomal storage disease. It is caused by an autosomal recessively inherited deficiency of the enzyme acid α-glucosidase (GAA) that hydrolyzes glycogen to glucose in the lysosome; the deficiency causes the deposition of glycogen in multiple tissues,…
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Author(s):
Edward T Carreras
,
Donna M Polk
Added:
3 years ago
Cardiovascular disease affects more than one-third of American adults and is the leading cause of mortality in the United States and worldwide.1 Only 4.5 % of those over the age of 20 meet the ideal levels of the seven metrics of cardiovascular health including cholesterol levels.1 Of modifiable risk factors, including smoking, hypertension, diabetes, and obesity, dyslipidemia has been shown to…
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Author(s):
Michael D McGoon
Added:
3 years ago
Pulmonary hypertension (PH) is a hemodynamic condition defined by pulmonary arterial systolic pressure (PASP) above an upper limit of 35mmHg, or by pulmonary arterial mean pressure (PAMP) exceeding 25mmHg at rest. Pulmonary arterial hypertension (PAH) is present when pre-capillary pulmonary vascular pressure is elevated in the absence of pulmonary capillary wedge pressure >15mmHg, such as that…
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Author(s):
Soraya M Samii
,
Javier E Banchs
Added:
3 years ago
Abstract
The concept of using an implantable device to manage arrhythmias and heart failure started over 50 years ago. Since then, we have seen these devices improve patient outcomes from bradyarrhythmias, atrial fibrillation, ventricular arrhythmias, and heart failure. These devices are now standard of care in the management of patients and include pacemakers, implantable cardioverter…
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Author(s):
Jack Collier
,
Arthur J Labovitz
Added:
3 years ago
The approach to the treatment of a variety of cardiovascular disorders has undergone remarkable change over the past two decades. The use of both percutaneous interventions in patients with acute myocardial infarction and automatic implantable cardiodefibrillators in patients with ventricular arrhythmias represent important examples. The cardiology community is currently in the process of another…
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Author(s):
Soraya M Samii
,
Javier E Banchs
Added:
3 years ago
The use of implantable devices to treat arrhythmias started with the implantable pacemaker back in the late 1950s. The risks and costs of implantation limited the indications for the procedure initially. A similar pattern was seen with the initial implantable cardioverter-defibrillators (ICDs) in the early 1980s. In the late 1990s, technology of both these devices focused on the management of…
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Author(s):
Zvonimir Krajcer
Added:
3 years ago
Annually, in the US approximately 15,000 deaths are caused by a rupture of an abdominal aortic aneurysm (AAA), making it the 13th leading cause of death. AAA is often referred to as ‘the silent killer’ and is estimated to affect 2.7 million Americans, half of whom are not correctly diagnosed.1 If left untreated, the risk of rupture is 80–90% through progressive thinning of the aortic vessel,…
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Author(s):
Giovanni Torsello
,
Konstantinos P Donas
Added:
3 years ago
Stroke is a leading cause of death and disability in the developed world.1 More than 750,000 strokes occur in the US annually,1 and one-third of these patients die during the first few months after their strokes. Acute carotid syndrome (ACS) is defined as a set of signs and symptoms linked to neurological deficits (transient ischemic attack [TIA] or ischemic stroke) caused by carotid occlusive…
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Author(s):
Gustavo A Lopera
,
Anne B Curtis
Added:
3 years ago
Cardiac pacing remains the only effective treatment for patients with symptomatic atrioventricular block (AVB). However, recent concern over the detrimental effects of chronic right ventricular (RV) pacing has motivated clinicians to look into the role of cardiac resynchronization therapy (CRT) in this group of patients. Chronic RV pacing causes ventricular dyssynchrony, which may lead to atrial…
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Author(s):
Debbie L Cohen
,
Raymond R Townsend
Added:
3 years ago
Chronic kidney disease (CKD) is increasingly prevalent, with an estimated 26 million adults with CKD in the US.1 Hypertension is the most common comorbidity in chronic kidney disease. At least 85% of patients with stage 3 CKD or greater have hypertension, making parenchymal kidney disease the most common ‘secondary’ form of hypertension. Treatment of hypertension can often be challenging, as…
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