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Author(s): Kimberly Atianzar , Peter Casterella , Ming Zhang , et al Added: 3 years ago
The foramen ovale is an important fetal structure that is integral to fetal circulation. During fetal development days 30–37, intra-atrial endothelial cells proliferate to form the septum primum and the ostium primum. The overlap between the these structures forms the inter-atrial passage known as the foramen ovale,1,2 which allows the fetal lungs to be bypassed by facilitating fetal blood… View more
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Inherited and Congenital Cardiac Conditions

Professor Lars Søndergaard is a consultant cardiologist at Rigshospitalet – Copenhagen, Denmark. Professor of Cardiology at University of Copenhagen, he published over 300 peer reviewed articles, and more than 15 textbook chapters. His research interests are focused on adults with congenital heart diseases and catheter-based heart valve interventions, as well as congenital and structural heart… View more
Prof Carlos Morillo is a cardiac electrophysiologist, currently serving in the Chief Division of Cardiology at theLibin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Prof Morillo has extensively researched Chagas disease since 1990, and was involved in the initial studies related to autonomic control in the different stages of the disease and the use of beta… View more
Author(s): Barry Love Added: 3 years ago
Children and adults with congenital heart disease are increasingly benefiting from non-surgical alternatives to repair their heart defects. The last decade has seen a remarkable advance in the tools and techniques used to treat congenital heart disease in the cardiac catheterization laboratory. This article summarizes a few of the important tools available in 2005. Atrial Septal Defect Secundum… View more
Author(s): Braghadheeswar Thyagarajan , Ankur Kalra , Alefiyah Rajabali , et al Added: 3 years ago
Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM), with a reported prevalence of AF in HCM of about 25 %.1 Patients with AF in HCM tend to be more symptomatic and have an increased stroke risk compared with patients without HCM.2 While the occurrence and treatment of (symptomatic) AF in HCM have been extensively studied, there is little data… View more
Author(s): Michael C Slack Added: 3 years ago
This is certainly an exciting time to be a congenital interventional cardiologist. No doubt the later part of the 20th century laid the foundation for the new millennium; however, since the centennial celebration, several milestone events have already occurred and the future looks as bright as ever. In late 2001, the Amplatzer Atrial Septal Occluder System┬«, became the first device ever to… View more
Author(s): Duraisamy Balaguru , Rajiv Verma Added: 3 years ago
Surgical repair has been the cornerstone of treatment for congenital heart diseases (CHD). However, cardiac catheterization has evolved from being a diagnostic modality to a therapeutic one in the past four decades. Application of catheter-based therapy has become the standard of care for some congenital heart defects, thus obviating surgery. This review will discuss congenital heart defects that… View more
Author(s): Steven Zweibel , Melissa Trelfa Added: 3 years ago
Continuous outpatient monitoring of a patient’s heart rhythm was initiated in 1949 with the invention of the Holter monitor by Norman J Holter. The early systems were bulky, recorded the heart’s rhythm for 24 or 48 hours onto a tape or cassette, and required that the data be analyzed by a technician after completion of the recording. As technology advanced, smaller devices (event recorders) were… View more
Author(s): Sara C Martinez , Sharonne N Hayes Added: 3 years ago
Pregnancy is a physiologic challenge, with significant hormonal, metabolic, and hemodynamic changes. Cardiac output is objectively increased by the fifth week after the last menstrual period and continues to grow by approximately 45 % by 24 weeks in the normal, singleton pregnancy. This is facilitated by elevations in heart rate and stroke volume and a decrease in systemic vascular resistance… View more