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FAME3: PCI Guided by FFR Didn't Meet Noninferiority for 1Y Outcomes Compared to CABG
Author(s): William Fearon Added: 2 years ago
In this short interview, Dr William F Fearon (Stanford University School of Medicine, US) discusses the findings from the FAME3 trial. This multicenter, international, randomized, controlled noninferiority trial investigated whether fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in patients with multivessel coronary artery disease (CAD) will result in similar… View more

Intervention
Author(s): Srinivas Murali Added: 3 years ago
Introduction Nearly five million Americans suffer from heart failure, with 550,000 new cases diagnosed with this disease each year. Heart failure is responsible for 11 million office visits and over 3.5 million hospitalizations per year in the US, with a total bill of US$23 billion spent annually on treatment. About 250,000 people in the US suffer from severe, end-stage heart failure (NYHA Class… View more

Heart Failure
Cerebral Embolic Protection Devices
Author(s): Ankit Agrawal , Toshiaki Isogai , Shashank Shekhar , et al Added: 1 year ago

Vascular Disease and Surgery

Intervention
Dual Antiplatelet Regimens for TAVR and Cardiac CT Evaluation of Leaflets
Author(s): Mirvat Alasnag , Waqar Ahmed , Ibrahim Al-Nasser , et al Added: 2 years ago

Anticoagulation

Imaging & Diagnostics
How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
Author(s): Carlos Vazquez-Sosa , Stacey D Clegg , James C Blankenship Added: 2 years ago

Prevention & Chronic Conditions
Author(s): Raif Tawakol Added: 3 years ago
Many patients on statin therapy understandably develop a false sense of security. They enjoy a lowered level of low-desity lipoprotein (LDL) and a risk reduction of some 35%. However, two out of three patients develop a myocardial infarction (MI) while on a statin therapy. Statins often do not increase HDL levels to any substantial degree (except for Rosuvastatin, which increases high-density… View more

Prevention & Chronic Conditions
Author(s): Donald E Cutlip Added: 3 years ago
Stent thrombosis has been recognized as a serious complication of coronary stent placement since the procedure was first reported in the 1980s.1 Subsequent aggressive peri-procedural anti-thrombotic strategies with inpatient transition to warfarin reduced the risk to about 3.5 % for subacute (30-day) stent thrombosis,2,3 a rate that would be unacceptable by current standards and did not account… View more

Prevention & Chronic Conditions

Intervention
Author(s): Michael N Young , Sammy Elmariah Added: 3 years ago
Severe aortic valve stenosis (AS) is chronic, progressive illness that confers significant morbidity and mortality. Once symptomatic, patients with severe AS will ultimately succumb to the disease if it is not promptly corrected.1 Historically, surgical aortic valve replacement (SAVR) served as the exclusive therapeutic option to correct this mechanical problem.2 However, in 2002, Alain Cribier… View more

Vascular Disease and Surgery

Intervention
Author(s): Christopher M Kramer Added: 3 years ago
Atherosclerosis is a systemic disease that can silently affect the entire vascular system and often manifests clinically as stroke, myocardial infarction or sudden cardiac death. Despite advances in diagnosis and treatment, the sequelae of atherosclerosis remain the leading cause of death in adult Americans. Traditionally the gold standard for the diagnosis and assessment of atherosclerosis… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Author(s): Michael D Almaleh , Scott Moore , Charles L Campbell Added: 3 years ago
Dual antiplatelet therapy with aspirin and thienopyridines (clopidogrel or ticlopidine) has become increasingly important in the management of patients with ischemic vascular disease. The combination of aspirin and clopidogrel has become the standard for the prevention of sub-acute stent thrombosis and protection against ischemic events in a variety of clinical scenarios including acute coronary… View more

Anticoagulation