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Author(s):
Shanmugam Uthamalingam
,
James L Januzzi
Added:
3 years ago
Several cardiac biomarkers may aid in the diagnostic and prognostic evaluation of acute and chronic heart failure. In this article we discuss more novel and emerging applications of such established cardiac biomarkers in heart failure and review emerging data for several other promising markers.
Novel Applications of Established Cardiac Biomarkers—Natriuretic Peptides
B-type natriuretic peptide…
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Yen-Wen Wu
Research Area(s) / Expertise:
Job title: Director
Author
Author(s):
James L Januzzi
Added:
1 year ago
HFSA 22 - Dr James Januzzi (Massachusetts General Hospital, US) outlines the findings of the PROVE-HF study, a trial which aimed to determine the effect of sacubitril/valsartan therapy on cardiac biomarkers in patients with mitral regurgitation in heart failure with reduced ejection fraction.
Questions:
1. What was the ideology behind PROVE-HF?
2. What is the mechanism of action behind…
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Evangelos Giannitsis
Job title: Assistant Professor of Medicine in Heidelberg
Author
Author(s):
James De Lemos
Added:
3 years ago
Acute coronary syndromes (ACS) is an umbrella term comprising a spectrum of clinical conditions ranging from unstable angina to non-ST elevation myocardial infarction and ST elevation myocardial infarction. ACS begins when an atherosclerotic plaque ruptures or erodes and a platelet-fibrin clot obstructs coronary blood flow. These critical disorders are a major cause of emergency medical care and…
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Author(s):
Aniket S Rali
,
Andrew J Sauer
Added:
3 years ago
In late December 2019, an outbreak of an unknown disease called a pneumonia of uncertain cause occurred in Wuhan, Hubei Province, China.1 Over the next few days, several independent laboratories identified the causative agent as a novel coronavirus.2–4 The WHO has temporarily named this virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the related infectious disease…
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Author(s):
Abelardo Martinez
,
Sandy Green
,
James L Januzzi
Added:
3 years ago
Previously considered to be separate disease entities, the acute coronary syndromes (ACS) are somewhat arbitrarily divided on the basis of their electrocardiographic manifestations and are now thought to arise from a common disease process. Based on a number of factors, the severity of the ACS and, consequently, their attendant clinical risk may vary. The management of patients with ACS should…
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Jose Alvarez-Cardona
Research Area(s) / Expertise:
Job title: Cardiologist
Author
Author(s):
Robert H Christenson
Added:
3 years ago
Accurate and timely biochemical marker testing for aiding the diagnosis of myocardial infarction (MI) has been important for the appropriate disposition and treatment of patients for the past several decades. Creatine kinase (CK) muscle and brain (CK-MB) mass and myoglobin measurements were the standard up to the mid-1990s, when assays for the cardiac-specific isoforms of troponin I and troponin…
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Author(s):
Sonika Malik
,
Anju Bhardwaj
,
Matthew Eisen
,
et al
Added:
3 years ago
Pulmonary embolism (PE) is a common and serious manifestation of venous thromboembolism (VTE) and is an important cause of morbidity and mortality in the US. The incidence is estimated to be 50 per 100,000 but increases to 500 per 100,000 in the elderly.1 There is a wide spectrum of clinical severity with mortality estimates of 1–2 % in stable individuals and up to 30 % in patients presenting…
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