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Dual Anti-platelet Therapy after Coronary Stenting: Rationale for Personalized Duration of Therapy
Author(s):
Donald E Cutlip
Added:
3 years ago
Article
Author(s):
Stefan H Hohnloser
Added:
3 years ago
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is associated with a five-fold increase in the risk of stroke and embolism.1 Oral anticoagulation (OAC) with warfarin reduces stroke by two-thirds compared with no treatment.1–3 Compared with aspirin, OAC reduces the risk of stroke by 45% and reduces cardiovascular events by 29%.4 However, it increases the risk of major bleeding…
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Vincenzo Russo
Job title: Chair of Cardiology
Author
Author(s):
Naga Venkata Pothineni
,
Srikanth Vallurupalli
Added:
3 years ago
Atrial fibrillation (AF) is the most common clinically relevant supraventricular arrhythmia. AF is a leading risk factor for stroke and accounts for about one-third of all ischemic cerebrovascular events.1 The last two decades have witnessed a paradigm shift in the management of AF with the development of catheter ablation and improvements in anticoagulant therapies. In this review, we discuss…
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Author(s):
Steven V Manoukian
,
Michele D Voeltz
,
Frederick Feit
Added:
3 years ago
Non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) include unstable angina (UA) and NSTE myocardial infarction (NSTEMI), and account for one and a half million hospitalisations in the US annually. Patients with ACS are typically managed by initial medical stabilisation followed by an early invasive approach, whereby cardiac catheterisation is performed, usually within 24 hours of…
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Author(s):
Manesh R Patel
Added:
1 year ago
In this short interview from our coverage of ACC.22 late-breaking trials, Dr Manesh Patel (Duke Heart Center, US) discusses the multicentre, randomised, double-blind PACIFIC-AF trial (Bayer)(NCT04218266).
The trial sought to determine the efficacy of the oral FXIa inhibitor asundexian and evaluate the safety of the drug, compared to the non-vitamin K oral anticoagulant (NOAC) apixaban, in…
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Author(s):
Ahmad Younes
,
Guilherme Ferragut Attizzani
,
Ankur Kalra
Added:
3 years ago
Transcatheter aortic valve replacement (TAVR) is a recent innovation that has transformed the care of patients with symptomatic severe aortic stenosis. It has emerged as an alternative for surgical aortic valve replacement (SAVR) in prohibitive-, high-risk, and more recently, intermediate-risk surgical patients. More than 200,000 TAVRs have been performed in 65 countries around the world.1
As…
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Author(s):
Paulus Kirchhof
Added:
7 months ago
ESC 2023 — Prof Paulus Kirchhof (University Heart & Vascular Center Hamburg, DE) discusses the findings of the NOAH-AFNET 6 trial (NCT02618577).
NOAH-AFNET 6 (Atrial Fibrillation Network, Daiichi Sankyo Europe) was an investigator-initiated, prospective, randomised trial aiming to demonstrate that oral anticoagulation using the NOAC edoxaban is superior to current therapy in stroke prevention,…
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Author(s):
Debra Green
,
Jack E Ansell
,
Stephan Moll
Added:
3 years ago
Oral anticoagulants are one of the most common causes of drug-induced adverse events.1 Expert dose management, which keeps the patient within a narrow therapeutic international normalized range (INR), is required to avoid adverse events and optimize therapy. Anticoagulation clinic (ACC) management has been shown to improve outcomes compared with the routine management provided by physicians,2 but…
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Author(s):
Johny Nicolas
,
Usman Baber
,
Roxana Mehran
Added:
3 years ago
Seminal clinical trials conducted in the balloon angioplasty and bare metal stent era established the superiority of dual antiplatelet therapy (DAPT) as compared with aspirin monotherapy or anticoagulation with respect to the prevention of thrombotic events.1,2 Other studies found that the benefits of DAPT are durable for at least 1 year and extend to patients with acute coronary syndromes.3–5…
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