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Management of Cholesterol in Diabetes - A Review

… Text Figures & Tables References Article Management of Cholesterol in Diabetes - A Review Mohit Gupta iD Borut Jug … and presence of small dense low-density lipoprotein [LDL] particles), LDL cholesterol lowering remains the primary target of lipid …

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Treating the Common Dyslipidemia in Patients with Type 2 Diabetes—Insights from FIELD on the Effects of Fenofibrate on CVD Risk

… and the guideline goal for low-density lipoprotein (LDL)-cholesterol may need to be lowered to 70mg/dl. Thus, it seems … even in the absence of dyslipidemia and possibly even when LDL-cholesterol levels are …

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Current Evidence and Future Directions of PCSK9 Inhibition

… monoclonal antibodies, evolocumab and alirocumab, reduce LDL cholesterol by 60% and improve cardiovascular outcomes when … that inhibits translation of PCSK9 mRNA, demonstrated LDL cholesterol reduction by 45-50% with the advantage of …

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Treating the Common Dyslipidemia in Patients with Type 2 Diabetes—The Effects of Fenofibrate on Cardiovascular Disease Risk

… and the guideline goal for low-density lipoprotein (LDL)-cholesterol may need to be lowered to 70mg/dl. Thus, it seems … even in the absence of dyslipidemia and possibly even when LDL-cholesterol levels are …

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Dyslipidemia: Current Therapies and Guidelines for Treatment

… to the development of coronary heart disease, and cholesterol-lowering treatment, primarily with statins, has … past few decades, and there is a clear association between LDL-C-lowering therapies and improved global outcomes from … on recommendations for appropriate patient selection for LDL-C-lowering therapies for primary prevention. This review …

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High Density Lipoprotein Cholesterol-The Next Battle Front in the Fight Against Heart Disease

… & Tables References Article High Density Lipoprotein Cholesterol-The Next Battle Front in the Fight Against Heart … They enjoy a lowered level of low-desity lipoprotein (LDL) and a risk reduction of some 35%. However, two out of … lipoprotein (HDL) by 8% to 14%), nor do they alter the LDL particle size, from small dense LDL to a larger, less …

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Proprotein Convertase Subtilisin/kexin Type 9 Inhibitors in Clinical Practice: A Focused Update

… 0 Abstract This article provides an updated review of the LDL-cholesterol efficacy, safety, and cardiovascular benefits of … liver that plays a significant role in the recycling of LDL receptors (LDLRs). 1,2 The LDLR, which normally recycles …

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High-density Lipoprotein Cholesterol — The Next Battle Front in the Fight Against Heart Disease

… Text Figures & Tables Article High-density Lipoprotein Cholesterol - The Next Battle Front in the Fight Against … They enjoy a lowered level of low-desity lipoprotein (LDL) and a risk reduction of some 35%. However, two out of … lipoprotein (HDL) by 8% to 14%), nor do they alter the LDL particle size, from small dense LDL to a larger, less …

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Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Inhibition in Patients With or at High Risk of Coronary Heart Disease

… that binds and inactivates the low-density lipoprotein (LDL) receptor onhepatocytes, leading to higher levels of serum LDL cholesterol (LDL-C). Individuals with 'loss of function' …

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Fibrates — The Other Life-saving Lipid Drugs

… (HDL), and small dense low-density lipoprotein (LDL) (atherogenic dyslipidemia), but the most recent … the American Diabetes Association (ADA) and the National Cholesterol Education Panel continue to focus on LDL control as the target of therapy. However, statin-based …

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