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Author(s):
Maria Teresa La Rovere
,
Roberto Maestri
,
Gian Domenico Pinna
Added:
3 years ago
Arterial baroreceptors play a crucial role in the adjustment of the cardiovascular system to several surrounding conditions. In a simplified paradigm, baroreceptor stimulation results in arterial pressure changes that can modulate both sympathetic and vagal activity and, as a consequence, heart rate and myocardial electrophysiological properties, contractility and vascular resistance. Arterial…
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Author(s):
Naomi Abe
,
John D Bisognano
Added:
3 years ago
Hypertension is the most common chronic disease in the US, affecting 29% of the adult population.1 Once considered a benign, compensatory mechanism for ageing, high blood pressure (BP) is now recognised as an important risk factor for cardiovascular disease. It is estimated that inadequate BP control is responsible for 62% of cases of cerebrovascular disease, 49% of cases of ischemic heart…
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Author(s):
Domenic A Sica
Added:
3 years ago
Hypertension is a major cause of morbidity and mortality worldwide.1–3 In the US, around 25% of the adult population has a blood pressure (BP) of ≥140/90mmHg, which is the defined cut-off value for hypertension.3 Although there are many effective pharmacotherapies available, many patients are not adequately controlled on their current antihypertensive regimens. The National Health and Nutrition…
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Author(s):
Deepak L Bhatt
,
Anna Meta Dyrvig Kristensen
,
Manan Pareek
,
et al
Added:
3 years ago
Hypertension is an important contributor to global morbidity and mortality and is a major burden on healthcare systems.1,2 More than 20% of the world’s population has high blood pressure when defined by conventional criteria: systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg.3,4 Even with therapeutic lifestyle and pharmacological measures, blood pressure remains poorly…
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Author(s):
Deepak Padmanabhan
,
Ameesh Isath
,
Bernard J Gersh
Added:
3 years ago
Endovascular techniques for renal denervation (RDN) as a treatment for hypertension were initially highly encouraging with reductions in blood pressure (BP) in the range of 30 mmHg.1 However, these high expectations received a major setback following the unexpected results of the sham-controlled Renal Denervation in Patients With Uncontrolled Hypertension (SYMPLICITY HTN-3) trial. This promising…
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Author(s):
John R Teerlink
Added:
3 years ago
Pulmonary arterial hypertension (PAH) is a progressive and debilitating disease with limited treatment options. Although some patients do well with calcium channel blockers, most ultimately need more advanced therapy, such as prostanoids. Recently, a new class of therapeutic agents has been developed to treat these patients: the endothelin receptor antagonists (ERAs). Although they are not…
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Author(s):
Mark Huffman
,
Vallerie V McLaughlin
Added:
3 years ago
Idiopathic pulmonary arterial hypertension (formerly referred to as primary pulmonary hypertension) is an uncommon yet progressively fatal disease defined by the presence of mean pulmonary artery pressure greater than 25mmHg at rest or greater than 30mmHg with exercise as tested by right heart catheterization in the absence of other etiologies for pulmonary hypertension. Across several studied…
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Author(s):
Myung H Park
Added:
3 years ago
Author(s):
John R Teerlink
Added:
3 years ago
Pulmonary arterial hypertension (PAH) is a progressive and debilitating disease with limited treatment options. Although some patients do well with calcium channel blockers, most ultimately need more advanced therapy, such as prostanoids. Recently, a new class of therapeutic agents has been developed to treat these patients: the endothelin receptor antagonists (ERAs). Although they are not…
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Author(s):
Robert P Frantz
Added:
3 years ago
Pulmonary arterial hypertension (PAH) is a rare but life-threatening condition that has traditionally required treatment with continuous intravenous epoprostenol via an indwelling central catheter.1–3 Such therapy improves outcome, but is fraught with side effects, expense, and risk of catheter-related complications. Therapy of PAH has evolved tremendously in recent years, reflecting the…
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